Fairness-Aware Client Selection for Federated Learning

Federated learning (FL) has enabled multiple data owners (a.k.a. FL clients) to train machine learning models collaboratively without revealing private data. Since the FL server can only engage a limited number of clients in each training round, FL client selection has become an important research problem. Existing approaches generally focus on either enhancing FL model performance or enhancing the fair treatment of FL clients. The problem of balancing performance and fairness considerations when selecting FL clients remains open. To address this problem, we propose the Fairness-aware Federated Client Selection (FairFedCS) approach. Based on Lyapunov optimization, it dynamically adjusts FL clients' selection probabilities by jointly considering their reputations, times of participation in FL tasks and contributions to the resulting model performance. By not using threshold-based reputation filtering, it provides FL clients with opportunities to redeem their reputations after a perceived poor performance, thereby further enhancing fair client treatment. Extensive experiments based on real-world multimedia datasets show that FairFedCS achieves 19.6% higher fairness and 0.73% higher test accuracy on average than the best-performing state-of-the-art approach.Comment: Accepted by ICME 202

Bone scaffolds loaded with siRNA-Semaphorin4d for the treatment of osteoporosis related bone defects.

Osteoporosis is a prominent disorder affecting over 200 million people worldwide. Recently, semaphorins have been implicated in the cell-cell communication between osteoclasts and osteoblasts and have been associated with the progression of osteoporosis. Previously, we demonstrated that knockdown of semaphorin4d (Sema4d) using siRNA delivered with a bone-targeting system prevented bone loss in an osteoporotic animal model. Here, we used this bone-specific technology containing siRNA-Sema4d and fabricated a PLLA scaffold capable of enhancing bone repair following fracture. We investigated the ability of the implant to release siRNA-Sema4d into the surrounding tissues over time and to influence new bone formation in a 3 mm femur osteoporotic defect model in ovariectomized rats. Delivery of the bone-targeting system released from PLLA scaffolds began 2 hours post-implantation, peaked at 1 day, and was sustained over a 21 day period. μCT analysis demonstrated a significantly higher bone volume/total volume bone mineral density and number of osteoblasts in the rats that were transplanted with scaffolds loaded with siRNA-Sema4d. These results confirm the specific role of Sema4d in bone remodeling and demonstrate that significant increases in the speed and quality of new bone formation occur when siRNA-Sema4d is delivered via a PLLA scaffold

Cocaine Preferentially Potentiates Fast Releasable Vesicle Pool in Mouse Dopaminergic Striatum In Vivo

BiophysicsSCI(E)CPCI-S(ISTP)0MEETING ABSTRACT2498A-499A10

The LAMOST Survey of Background Quasars in the Vicinity of the Andromeda and Triangulum Galaxies -- II. Results from the Commissioning Observations and the Pilot Surveys

We present new quasars discovered in the vicinity of the Andromeda and Triangulum galaxies with the LAMOST during the 2010 and 2011 observational seasons. Quasar candidates are selected based on the available SDSS, KPNO 4 m telescope, XSTPS optical, and WISE near infrared photometric data. We present 509 new quasars discovered in a stripe of ~135 sq. deg from M31 to M33 along the Giant Stellar Stream in the 2011 pilot survey datasets, and also 17 new quasars discovered in an area of ~100 sq. deg that covers the central region and the southeastern halo of M31 in the 2010 commissioning datasets. These 526 new quasars have i magnitudes ranging from 15.5 to 20.0, redshifts from 0.1 to 3.2. They represent a significant increase of the number of identified quasars in the vicinity of M31 and M33. There are now 26, 62 and 139 known quasars in this region of the sky with i magnitudes brighter than 17.0, 17.5 and 18.0 respectively, of which 5, 20 and 75 are newly-discovered. These bright quasars provide an invaluable collection with which to probe the kinematics and chemistry of the ISM/IGM in the Local Group of galaxies. A total of 93 quasars are now known with locations within 2.5 deg of M31, of which 73 are newly discovered. Tens of quasars are now known to be located behind the Giant Stellar Stream, and hundreds behind the extended halo and its associated substructures of M31. The much enlarged sample of known quasars in the vicinity of M31 and M33 can potentially be utilized to construct a perfect astrometric reference frame to measure the minute PMs of M31 and M33, along with the PMs of substructures associated with the Local Group of galaxies. Those PMs are some of the most fundamental properties of the Local Group.Comment: 26 pages, 6 figures, AJ accepte

Compound-based Chinese medicine formula: From discovery to compatibility mechanism.

ETHNOPHARMACOLOGICAL RELEVANCE: Chinese medicine formula (CMF) has a long history of clinical use in the treatment of various diseases under the guidance of traditional Chinese medicine (TCM) theory. The application of CMF can be divided into three levels, crude extracts, homologous compounds mixture, and specific compounds. However, the modern scientific connotation of the CMF theory has not been clarified. AIM OF THE REVIEW: To critically evaluate the research strategy for the investigation of compound-based CMF (CCMF). MATERIALS AND METHODS: The related information was collected from the scientific databases, including CNKI, Elsevier, ScienceDirect, PubMed, SpringerLink, Web of Science, and Wiley Online. RESULTS: The research design including discovery, screening, optimization, pharmacodynamics models, and target research techniques including the targets for compatibility compounds were evaluated. Essentially it has been evaluated that the in vitro multicellular three-dimensional culture or organoid model has been proposed for the optimization model for compatibility research of CCMF. Based on these, the traditional compatibility theory of CMF, such as Monarch-Minister-Assistant-Guide (Jun-Chen-Zuo-Shi in Chinese), can probably be elucidated by the CCMF research. CONCLUSIONS: CCMF has the clear advantage of providing the exact composition and controllable quality of modern medicines, in addition to having the characteristics of multi-ingredients and multi-targets synergistic effects of TCM. However, CCMF is still associated with challenges which need to be addressed for its future use

Application of Grey System Model to Forecast the Natural Gas Imports in China

China’s natural gas imports will keep an upward trend in the future due to its increasing demands. A comparatively accurate prediction of natural gas imports will help the Chinese government make appropriate decisions when formulating energy policies. In this paper, a new grey predication model, GPM_NGI model, was proposed to forecast China’s natural gas imports. Compared with GM (1, 1) and DGM (1, 1) model, the proposed new model performed better in the simulation process and bore smaller mean relative percentage error when used in simulating China’s natural gas imports from 2011 to 2019. Then, the new model was employed to forecast China’s natural gas imports from 2020 to 2022. The results showed that China’s natural gas imports would continue to grow rapidly over the next three years. Therefore, in order to strike a balance between the natural gas supply and demand in the future and avoid overdependence on imports, the Chinese government should take effective measures from both the supply and demand ends, such as making better use of shale gas, wind, and solar energy as well as reducing the industrial dependence on natural gas

Application of Visual Interactive Concept Map in College English Writing Teaching

In order to solve the problem of students' poor thinking in English writing, this paper adopts the concept map method. The visual interactive concept map was tested in 6 levels and 9 types of universities. The test results indicate the method can stimulate students' interest in learning and improve their ability of autonomous learning and increasing the effect of college English writing teaching. The method can also stimulate students' interest in learning and improve their ability of autonomous learning and increasing the effect of college English writing teaching